Dr. Koyano focuses on patent prosecution mainly in the US. She has 30 years of research experience in areas including stem cell biology, developmental biology, embryology, neuroscience, immunology, molecular biology, and biochemistry. She is an inventor on several US patents and patent applications.

Technology Areas

• Life Sciences
• Medical Biology
• Chemistry

Language Skills

• English
• Japanese

Education

• University of Tokyo – Tokyo, Japan
  • Ph.D., Biochemistry and Biophysics
• University of Tokyo – Tokyo, Japan
  • M.S. Biochemistry and Biophysics
• University of Tokyo – Tokyo, Japan
  • B.S., Biochemistry and Biophysics

Bar Admissions

• United States Patent and Trademark Office

Publications

(For a full publication list, please search PubMed for Koyano-Nakagawa).

• Generation of human endothelium in pig embryos deficient in ETV2. Nat Biotechnol. 2020 Mar;38(3):297-302.
• A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human. Nat Commun. 2018 Oct 12;9(1):4237.
• TCM visualizes trajectories and cell populations from single cell data. Nat Commun. 2018 Jul 16;9(1):2749.
• DrImpute: imputing dropout events in single cell RNA sequencing data. BMC Bioinformatics. 2018 Jun 8;19(1):220.
• Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis. PLoS One, 2017; e0189010.
• Etv2 as an essential regulator of mesodermal lineage development. Cardiovascular Research, 2017; 1131294.
• Dpath software reveals hierarchical hemato-endothelial lineages using of Etv2- progenitors based on single cell transcriptome analysis. Nature Communications, 2017; 8:14362.
• Endoglin integrates BMP and Wnt signaling to induce hematopoiesis through JDP2. Nature Communications, 2016; 7:13101.
• Lift NIH restrictions on chimera research. Science. 2015;350(6261):640.
• Etv2-miR-130a network regulates mesodermal specification. Cell Reports, 2015; 13(5):915-23.
• Feedback mechanisms regulate Ets variant 2 (Etv2) gene expression and hematoendothelial lineages. J Biol. Chem, 2015: 290(47):28107.
• Human induced pluripotent stem cell-derived cardiomyocytes as a model for heart development and congenital heart disease. Stem Cell Reviews and Reports, 2015; 11(5):710.
• Hedgehog signaling during appendage development and regeneration. Genes, 2015; 6(2): 417.
• Kelch repeat and BTB domain containing protein 5 (Kbtbd5) regulates skeletal muscle myogenesis through the E2F1-DP1 complex. J Biol Chem, 2015; 290(24):15350-61.
• Cardiomyopathy in a dish: Using human inducible pluripotent stem cells to model inherited cardiomyopathies. Journal of Cardiac Failure, 2015; 21(9):761.
• The transcription factor, Mesp1, interacts with cAMP responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. Journal of Biological Chemistry, 2015; 290(15): 9614.
• Inferring dynamic gene regulatory networks in cardiac differentiation through the integration of multi-dimensional data. BMC Bioinformatics, 2015; 2015;16(1):74.
• Inferring gene regulatory networks by context dependent and independent effects. Journal of Medical Devices, 2015; 9(3):030947.
• Visualizing vascular structure in the adult newt (notophtalmus viridescens) heart. Journal of Medical Devices, 2015; 9(2):020917.